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hypoattenuating foci liver

to maintaining your privacy and will not share your personal information without Check with your doctor. (2021). We can not tell the diagnosis from simply hearing they are hypoattenauting. If it does cause problems, your symptoms will depend on the type you have. Chapman S, Nakielny R. Aids to radiological differential diagnosis. I was found on recent ct of the abdomen with iv contrast to have hypoattenuating foci of my liver with thickening of my adrenal glands. For more information, please refer to our Privacy Policy. What does hypoattenuating mean as a characterization of an observed area on the liver? CONCLUSION. Some benign tumors require treatment while others dont. jacr.org/article/S1546-1440(17)30889-X/fulltext, wchh.onlinelibrary.wiley.com/doi/full/10.1002/tre.777, cancer.net/cancer-types/liver-cancer/statistics, 7 Ways to Improve the Health of Your Liver, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, David Crosby Lived Nearly 3 Decades After Liver Transplant: Why That Matters, Heres How Fast Food Can Impact Your Liver, develops in the bile ducts that connect your liver to your gallbladder, rare cancers of the cells that line your livers blood vessels, a very rare cancer that develops in children, metastasis means the cancer has spread from another organ where the cancer started; in this case, it spreads to the liver, may need treatment if the lesion is more than 5 centimeters (cm) wide or causing symptoms, treatment may be needed if cysts cause symptoms or theyre more than, solid noncancerous lesions on an otherwise healthy liver, clusters of blood vessels that create tumors on your liver, caused by an increase in the number of functional cells, consuming food contaminated with the fungus, exposure to vinyl chloride and thorium dioxide, ongoing use of birth control pills or anabolic steroids, being of childbearing age in people assigned female at birth, targeted medications to stop cancer cells from growing, getting treatment for conditions that can cause liver cancer, such as hemochromatosis, eating a balanced diet to minimize the risk of developing, avoiding recreational anabolic steroids (these are different than steroid injections used to treat health conditions), avoiding behaviors that can increase your chances of contracting hepatitis, such as injected drug use and sex without a barrier method, like a condom. Benign lesions are noncancerous growths. few tiny foci 6mm in gall bladder. The differential diagnosis for hypodense lesions on a ct scan of the liver is quite expensive. Hypoattenuating lesions are commonly referred to in regards to the liver or kidneys. What does hypoattenuating mean as a characterization of an observed area on the liver? Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Liver lesions are any abnormal growths on your liver. The presence of a hypoattenuating lesion can either mean that there is a simple cyst or small sore on the surface of the organ, or it could indicate the presence of a tear or much more serious issue such as a malignant tumor. The hyper-in-hypoattenuating lesions showed more rapid progression to entirely enhanced lesions. Liver lesions are abnormal growths of cells in the liver. Sounds like the more appropriate ICD-10 code for your finding was K80.20 = Calculus of gallbladder w/o cholecystitis w/o obstruction. Liver lesions are abnormal growths that occur for a variety of reasons. If MRI was truly inconclus Small intrahepatic lesions are not on their own likely to cause abdominal pain. Doctor: . We refer to the brightness of a lesion as density. Several intrinsic liver pathologies can cause a diffuse change in liver attenuation with increased hepatic fat being the most prevalent. By the retrospective review of preoperative helical CT scans in 1,133 consecutive patients with proved gastric and colorectal cancers, 289 patients (25.5%) with 947 SLAHs (15 mm) were selected. This can represent something like a cyst or solid nodule. Our mission is to help you understand your radiology reports by explaining complex medical terms in plain English. Other imaging features of these lesions help us make a diagnosis. They dont spread to other areas of your body and dont usually cause any health issues. Histologically, FNH is not a tumor and consists of benign-appearing hepatocytes occurring in a liver that is otherwise normal (i.e. Liver cancer does not cause symptoms in its early stages. By using our website, you consent to our use of cookies. The appearances of multiple biliary hamartomas of the liver (von Meyenberg complexes) on computed tomography. Cooke JC, Cooke DA. It is common to see these lesions in the kidneys, pancreas, liver and spleen. Focal hypodense hepatic lesions on a non-contrast CT scan can result from a number of pathological entities, including: neoplasms benign hepatic hemangioma adenoma biliary hamartoma: von Meyenberg complexes 2 malignant hepatoma/hepatocell. They are benign and very common. Post-Doctoral Degree. Hepatic attenuation on CT, reflected by Hounsfield values, depends on a combination of factors including the presence or absence, as well as the phase, of IV contrast administration. Keep reading to learn more about how liver lesions are classified, what causes them, and when treatment is needed. We do not endorse non-Cleveland Clinic products or services. E-mail: [emailprotected]. Jacobs JE, Birnbaum BA, Shapiro MA et-al. Liver lesions can be used to describe an area of cancer (from liver or from other areas) but can also be used to describe hemangiomas (collection of b Liver lesion is another way to describe a mass in the liver. Although your liver itself doesn't feel pain, problems in your liver can cause pain or discomfort in other places, usually throughout your abdomen. They are usually small and occur in up to 20% of humans. At late arterial phase, FNH typically presents with a bright homogeneous enhancement, but less intense than the aorta with a hypodense central scar. Usually it means a cystic lesion which is a common and benign finding. Pediatrician. Cleveland Clinic is a non-profit academic medical center. Attenuation in the liver and in both hyperattenuating and hypoattenuating lesions did not differ between mono and mono+ (P = 0.41-0.49 The cumulative attenuation conversion rates for the 60 hypoattenuating lesions were 15.8%, 44.3%, and 58.7% at 1, 2, and 3 years. Because a small liver cyst doesn't usually cause symptoms, it can go undiagnosed for years. O'riordan E, Craven CM, Wilson D et-al. Although most lesions arent harmful, its still critical to receive a proper diagnosis. Often the, Read More What Does IT Mean: Can Not Exclude Something?Continue, Please read the disclaimer Lymphoscintigraphy for breast cancer is a common and helpful procedure done prior to surgery for breast cancer. hepatic hemangioma : commonest hyperechoic liver lesion by far . A hemangioma was defined as a hypoattenuating lesion with peripheral nodular globular enhancement and centripetal fill-in. Conclusion: Hypoattenuating hepatic nodular lesions in chronic liver disease depicted on dynamic CT have high malignant potential and should be followed with special attention to conversion from hypoattenuation to hyperattenuation to determine the optimal timing of treatment. Gore RM, et al. The purpose of this study was to determine the prevalence and significance of small low attenuating hepatic lesions (SLAHs) seen on helical CT in preoperative patients with gastric and colorectal cancers and to find differentiating features of benign from malignant SLAH. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Benign lesions typically do not cause symptoms, especially when they are small. 1986;159 (2): 355-6. There are many different types of masses and they can be benign or malignant. Dr. Carlo Hatem answered Pulmonary Critical Care 27 years experience Usually yes: There are features on your test that can give you an idea if these lesions are concerning or not. diffused fatty liver change,mild Read More Hepatic steatosis is the medical term that describes the accumulation of fat or lipids within liver cells, or hepatocytes. shoulder pain. Your provider may monitor them by repeating imaging. Portal vein drains venous blood from the GI tract and other parts of the splanchnic area. Minimize fats - saturated fats, trans-fats, and fermented foods can aggravate symptoms, such as bloating Dandelion root - helps to alleviate some of the symptoms linked to cysts Lemon juice -. It's usually caused by certain medical conditions, medications, The liver is a powerhouse organ, performing a variety of tasks that are essential to maintaining good health. Hypoattenuating lesions can represent many diagnosis in these organs. (2022). Wien Klin Wochenschr. There are features on your test that can give you an idea if these lesions are concerning or not. Address correspondence and reprint requests to Dr. H. K. Lim at Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-dong, Kangnam-gu 135-710, Seoul, Korea. Some may even be harmful. I agree. Our website services, content, and products are for informational purposes only. Top answers from doctors based on your search: Created for people with ongoing healthcare needs but benefits everyone. The most common cause of "tiny echogenic foci throughout the liver" is punctate calcification secondary to prior granulomatous infection. I was found on recent ct of the abdomen with iv contrast to have hypoattenuating foci of my liver with thickening of my adrenal glands. This a serious problem. Feeling full after eating small amounts of food. Imaging is a crucial step in diagnosing these conditions as liver enzymes can be elevated in up to 9% of individuals in the USA. feelings of abdominal fullness or bloating. Some benign lesions dont require any treatment if theyre not causing symptoms. Radiologic and pathologic features of common and/or critical tumor or tumor-like diagnoses (lesions) of the liver are discussed within. However, unenhanced CT also plays an important role in revealing so-called hyperattenuating signs, which represent a slight increase in the focal attenuation of a vessel. Aflatoxin: This toxin is created when mold grows on grain and nuts that arent stored the right way. Cyst can Liver lesions implies that there are areas where the homogeneity of the liver is not complete. The size of the liver lesion is an important consideration in guiding the evaluation: Lesions smaller than approximately 1.0 cm are commonly benign incidental findings on imaging studies, and in most cases represent small cysts, hemangiomas, or biliary hamartomas. I am a trainee of radiology & have a query. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/benign-liver-tumors/#information-for-the-newly-diagnosed), (https://patient.info/doctor/benign-liver-tumours), (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338186/). heartburn. The problem arises when the concentration of triglycerides exceeds the normal levels. Hypoattenuating lesion interpolar left renal cortex. female 49? 6. If tumors grow large, they may cause symptoms and need to be removed. Possible causes include: The symptoms you experience depend on the type of liver lesion. For example, a liver cyst, containing fluid, would be hypoattenuating compared to solid liver tissue. Your doctor may call them a mass or a tumor. Diffuse liver disease: strategies for hepatic CT and MR imaging. Opportunistic Screening for Hereditary Hemochromatosis With Unenhanced CT: Determination of an Optimal Liver Attenuation Threshold. For potential or actual medical emergencies, immediately call 911 or your local emergency service. On rare occasions, they can become large enough to press on nearby organs. Your doctor can diagnose liver lesions with a combination of imaging, blood tests, and sometimes a small tissue sample. However, a biopsy may be needed in difficult cases. . Id say that, Read More Is A Non Contrast CT Of The Abdomen Enough?Continue. A liver hemangioma (he-man-jee-O-muh) is a noncancerous (benign) mass in the liver made up of a tangle of blood vessels. See prior answer regarding differential for benign ones. Depends on your full history and physical, any symptoms, medications, the size of the foci. The presence of a hypoattenuating lesion can either mean that there is a simple cyst or small sore on the surface of the organ, or it could indicate the presence of a tear or much more serious issue such as a malignant tumor. Boll DT, Merkle EM. Dr. Michael Gabor answered Diagnostic Radiology 35 years experience It generally means: it is of lower density than normal liver tissue. This means that there is no blockage or anatomical problem of the gallbladder. What does hypoattenuating mean as a characterization of an observed area on the liver? Liver is divided in eight functionally independent segments and numbered one to eight. Liver lesions are groups of abnormal cells in your liver. No news about your CT report simply means that the results of the scan are not yet available to you. Any serious liver disease would be detected by mri. 9. Benign. If you are at risk or experiencing symptoms, talk to your healthcare provider. no pain. Please try after some time. The top risk factor for liver cancer is chronic viral hepatitis. Kodama Y, Ng CS, Wu TT et-al. It is common to see these lesions in the kidneys, pancreas, liver and spleen. Fatty liver disease means that you have excess fatty acids in your liver. At the time the article was created Yuranga Weerakkody had no recorded disclosures. All rights reserved. Multiple hypoattenuating foci involving the subcortical white matter (white arrows in A-C), as well as the corpus callosum (white ellipse in A and B), the anterior limb of the internal capsule . Pathology AJR Am J Roentgenol. Check for errors and try again. Many do not need treatment. , , , Diffuse liver changes in the child. Although primary liver tumors are mostly hypervascular, there are exceptions. Radiographics. Learn about symptoms, causes. The lesion could still be the same size, but the reported measurements can differ because of slight differences in the manual placement of the measure To improve your prognosis, my primary suggestion is to research the ideal ways to optimize your nutrition as your GI system has been affected. "the liver demonstrates homogeneous signal intensity without focal lesion"? What Does IT Mean: Can Not Exclude Something? These are difficult to diagnose and difficult Last medically reviewed on April 28, 2022. The most common type of benign liver lesion, a liver hemangioma is an abnormal mass of blood vessels. 4. The association between the presence, size, and number of small hypoattenuating hepatic lesions at initial CT and the subsequent development of metastases was analyzed by using Kaplan-Meier analysis. A liver lesion can be caused due to various underlying health complications. To learn more, please visit our. Commonly, diffuse hepatic steatosis is indicative of fatty liver disease. A, Transarterial chemoembolization (TACE): This is a targeted type of chemotherapy that takes anti-cancer drugs directly to the lesion. Anyone can have a liver lesion, but some things can make youmore likely to have cancerous ones: Benign liver lesions usually dont cause any symptoms. The hypodense (darker) nodule in the liver could be due to a tumor, cyst or sometimes hemangioma. Without more information, the answer is "Yes" & this should not be ignored. Is it possible for a lesion in liver to grow from app 1 cm to 2 cm in about 1-1/2 months? But some liver lesions form as a result of cancer. Unable to process the form. Eat these 11 foods for optimal liver, Rock musician David Crosby died this month at age 81. What are the risk factors for liver lesions? The following factors may also increase the risk of developing liver lesions, leading to liver cancer. no cirrhosis). Find the latest information from the globally recognized leader in digestive diagnosis, treatments and surgical innovations. What percentage of kidney lesions are cancerous? Allowing for all these factors, the mean unenhanced attenuation value is around 55 HU 4. Symptoms of a liver cyst. A cyst of 5 mm is quite common for people above 30 years old. Imaging tests: These can show where a lesion is on your liver and how big it is. Hepatic attenuation on CT. Reference article, Radiopaedia.org (Accessed on 04 Mar 2023) https://doi.org/10.53347/rID-8020, {"containerId":"expandableQuestionsContainer","displayRelatedArticles":true,"displayNextQuestion":true,"displaySkipQuestion":true,"articleId":8020,"questionManager":null,"mcqUrl":"https://radiopaedia.org/articles/hepatic-attenuation-on-ct/questions/2005?lang=us"}. Getting the hepatitis B vaccine and proper treatment for viral hepatitis can lower your risk of liver cancer. Diagnostic criteria for fatty infiltration of the liver on contrast-enhanced helical CT. AJR Am J Roentgenol. 1998;171 (3): 659-64. Llovet JM, et al. Next, they may order a combination of blood tests and imaging. Lawrence EM, Pooler BD, Pickhardt PJ. A "flow" study is usually recommended because a biopsy of a vascular lesion . major concern or not? Malignant lesions are cancerous. There are many types of liver disease, ranging from those that are treatable to those that require a liver transplant. This is especially true when we do not know what it is and additional testing may be needed. But you can lower your liver cancer risk by: The outlook is often good. Short description: Abnormal findings on dx imaging of liver and biliary tract The 2023 edition of ICD-10-CM R93.2 became effective on October 1, 2022. (2018) AJR. (2021). Noncancerous, or benign, liver lesions are common. After a median follow-up of 584 . Jang, Hyun-Jung; Lim, Hyo K.; Lee, Won Jae; Lee, Soon Jin; Yun, Jee Yeong; Choi, Dongil. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. They found this new 3 mm hypoattenuating focus in liver but they are not labeling this as metastatic disease. Most hypovascular lesions are malignant and metastases are by far the most common. For example, a liver cyst, containing fluid, would be hypoattenuating compared to solid liver tissue. A heterogeneous liver can be caused by fatty liver disease, tumors or cirrhosis. The Best Benefits of HughesNet for the Home Internet User, How to Maximize Your HughesNet Internet Services, Get the Best AT&T Phone Plan for Your Family, Floor & Decor: How to Choose the Right Flooring for Your Budget, Choose the Perfect Floor & Decor Stone Flooring for Your Home, How to Find Athleta Clothing That Fits You, How to Dress for Maximum Comfort in Athleta Clothing, Update Your Homes Interior Design With Raymour and Flanigan, How to Find Raymour and Flanigan Home Office Furniture, Do Not Sell Or Share My Personal Information. Doctors typically provide answers within 24 hours. The finding was multiple hypoattenuating foci in the right lobe of the liver. liver lesions shrank. A primary risk factor of malignant liver lesions (hepatocellular carcinoma) is long-term hepatitis B or hepatitis C infection. Interpret the result The main focus of the working group was to expand upon the body of work produced by the ACR on the management of incidental imaging findings. Measurement of tissue-bound amiodarone and its metabolites by computed tomography. Liver cancers always need treatment. no financial relationships to ineligible companies to disclose. Like all cancers, cancerous lesions of the liver are caused by changes to the DNA that make cells replicate uncontrollably. It means that the liver is not functioning well. For these, please consult a doctor (virtually or in person). Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. I had this same test done in 2018 and nothing showed up at all for Liver? Dual phase hepatic CT: influence of scanning direction on liver attenuation. they were not concerned about it in 2013? You might not know you have them. The symptoms you experience depend on the type of liver lesion. Journal of Computer Assisted Tomography26(5):718-724, September-October 2002. CT scans can detect the additional fatty structures in the liver, which appear on the scan as areas of lighter-colored tissue, according to an article in The Oncologist. What does this mean is it bad? 2018;130(5-6):220-1. Hypoattenuating lesions can represent anything from benign abnormalities like cysts which contain fluid to cancerous abnormalities like tumors and metastasis (cancer spread). Liver cysts are fluid-filled sacs that form in the liver. The prevalence (25.5%) of SLAH on helical CT was higher than that reported on conventional CT; however, metastases only presenting as SLAH were rare (2.2%). We avoid using tertiary references. As the lesion grows, you may experience: There is no single test that can diagnose all liver lesions. In the uterus, a Hypoattenuating lesion is most commonly a fibroid. Benign lesions typically do not cause symptoms, especially when they are small. As a tumor grows larger, it can cause liver dysfunction or problems by pushing on other tissues. Last reviewed by a Cleveland Clinic medical professional on 05/18/2021. Yun JY, Choi D. Small hypoattenuating lesions in the liver on single-phase helical CT in preoperative patients with gastric and colorectal cancer: prevalence, significance, and . Liver lesions are abnormal growths that have various causes. The attenuation of these signs tends to increase because the concentration of hemoglobin increases . Dr. Shelby Terstriep answered Internal Medicine 22 years experience Depends: Liver lesions can be used to describe an area of cancer (from liver or from other areas) but can also be used to describe hemangiomas (collection of b. You can get vaccinated against hepatitis B, wear condoms when you have sex, and dont share needles if you use them to do recreational drugs. Most people who have benign or cancerous liver cysts never have symptoms. This usually refers to a nodule or spot which is darker then the normal thyroid. Among 881 SLAHs in 268 patients, 693 (78.3%) in 248 patients (92.5%) were benign, and 188 (21.2%) in 30 patients (11.2%) were metastases; 10 patients (3.7%) had both. This question is best answered by a gastroenterologist or hepatologist(liver specialist). Allowing for all these factors, the mean unenhanced attenuation value is around 55 HU 4. Hepatocellular lesions (focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma), biliary lesions (mucinous cystic neoplasm and intrahepatic cholangiocarcinoma), vascular mesenchymal lesions (cavernous hemangioma . What are most common symptoms of early colorectal liver metastasis?if small liver lesions are clm, how fast do they grow big enough to be chacterized? The criteria of SLAH were as follows: (1) 15 mm or smaller, (2) lower attenuation compared with the surrounding hepatic parenchyma, and (3) other than the dilated bile duct, periportal low attenuation, unenhanced vessels, or partial volume averaging of adjacent structures. HIDA allows dynamic assessment of hepatic function and evaluation of biliary system integrity and function. Specialized cytology/staining tests of ones pathologic specimen, requested at the time of surgery, can give prognostic information concerning tumor gr enough information to venture a guess. These symptoms usually occur when a cyst starts . Liver lesions can have different measrmnts in ct vs us, where ct is more acurate.can measurements also be differece between ct and mri? For example, a liver cyst, containing fluid, would be hypoattenuating compared to solid liver tissue You have to discuss these questions with doctor who know your symptoms and send you to the CT. Clin Radiol. Is A Non Contrast CT Of The Abdomen Enough. 2005-2023 Healthline Media a Red Ventures Company. Polycystic liver disease (PLD) is the development of multiple cysts in the liver. Hepatobiliary scintigraphy with iminodiacetic acid (HIDA) derivatives is the dominant nuclear medicine study employed for the assessment of the liver and biliary systems. Data is temporarily unavailable. It isn't until the cyst enlarges that some people experience pain and . Learn how we can help Reviewed Oct 28, 2022 Thank Dr. Frank Kuitems agrees 1 thank Dr. Birendra Tandan answered Urology 35 years experience Hypodense is a descriptive term used by radiologists to describe an abnormality in the liver seen on a ct scan. Yellowing of the skin or whites of your eyes from. Found in around 5 percent of adults, they are asymptomatic and typically go undiscovered. Most liver metastases are multiple, involving both lobes in 77% of patients and only in 10% of cases there is a solitary metastasis. 2. The term hypoattenuating is used when describing something on the image that is brighter in color than everything else. A hyperechoic liver lesion on ultrasound can arise from a number of entities, both benign and malignant. In the abdomen, Hypoattenuating lesions can be found in any organs. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Presence of a layer of ascites. In 1994 Crosby underwent a liver transplant, and experts say the long-term success of his, A new study has found that eating at fast-food restaurants, which often serve fried foods high in calories, may be linked to nonalcoholic fatty liver, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It needs further . Connect with a U.S. board-certified doctor by text or video anytime, anywhere. 2007;188 (5): 1307-12. In your case, there is not enough information provided to assess whether it is a significant finding or not. 1994;49 (1): 14-8. American Liver Association: Benign Liver Tumors., Cleveland Clinic: Malignant Hepatic Lesions., California Pacific Medical Center: Metastatic Liver Lesions Diagnosis and Treatment, Non-Cancerous Liver Lesions Diagnosis and Treatment., Memorial Sloan Kettering Cancer Center: Liver Cancer Prevention & Risk Factors.. Clin Radiol. For these, please consult a doctor (virtually or in person). WebMD does not provide medical advice, diagnosis or treatment. 10% of HCC is hypovascular. Saunders Ltd. (2003) ISBN:0702026506. Copy. MeSH terms Aged Carcinoma, Hepatocellular / complications* Purpose: The purpose of this study was to determine the prevalence and significance of small low attenuating hepatic lesions (SLAHs) seen on helical CT in preoperative patients with gastric and colorectal cancers and to find differentiating features of benign from malignant SLAH. (2017). Only a small number of these growths are cancerous. may email you for journal alerts and information, but is committed Wolters Kluwer Health Most lesions are noncancerous and dont require treatment if theyre small and dont cause symptoms. They may recommend specialized testing or monitoring to check for changes that require additional care. i noticed on my results from a ct scan that i have a tiny hypoattenuating lesion on my liver. Can a lesion on the liver be from a fatty liver? Also known as hepatic hemangiomas or cavernous hemangiomas, these liver masses are common and are estimated to occur in up to 20% of the population. Hypoattenuating hepatic nodular lesions in chronic liver disease depicted on dynamic CT have high malignant potential and should be followed with special attention to conversion from hypoattenuation to hyperattenuation to determine the optimal timing of treatment. And if imaging studies show signs of a liver lesion, remember that it might not be serious. The second most common cause are focal nodular hyperplasia which occurs in about 5% of humans. Hypoattenuating is a term used by radiologists, particularly when we are not clear about the diagnosis. Additional testing may be needed to include additional imaging tests.

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hypoattenuating foci liver

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